Main Article Content
Abstract
Type 2 diabetes mellitus (T2DM) is a major non-communicable disease in Indonesia and is commonly diagnosed using fasting blood glucose (FBG) levels. Recent studies have suggested a potential association between fasting blood sugar (FBS) and uric acid, which plays a role in oxidative stress and glucose metabolism, although findings have been inconsistent. This study aimed to examine the association between blood uric acid levels and FBG levels in T2DM patients at ODSK Regional Hospital, North Sulawesi, Indonesia, given the rising prevalence of T2DM and related metabolic disorders in the region. A cross-sectional study was conducted using secondary data from medical records of T2DM patients between July 2023 and July 2024. Among male patients, 25 percent had uric acid levels between 3.0 and 7.4 mg/dL, while 28.8 percent had levels above 7.4 mg/dL. Among female patients, 32.7 percent had uric acid levels between 2.1 and 6.3 mg/dL, and 13.5 percent had levels above 6.3 mg/dL. Additionally, 84.6 percent of all patients had FBG levels of 126 mg/dL or higher. Statistical analysis showed no significant correlation between blood uric acid levels and FBG levels (ρ = 0.541; r = 0.541), suggesting that there is no significant association between these two variables in this population.
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Copyright (c) 2025 Fathin Gafur, Youla Assa, Murniati Tiho

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
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- Husen F, Ratnaningtyas NI. Relationship between Uric Acid Levels and Blood Glucose in Old Adult Women in Mandiraja Wetan Village. Journal of Research and Community Service UNSIQ 2023;10:177–85. https://doi.org/10.32699/ppkm.v10i3.5371.
- Komariah K, Rahayu S. Relationship of Age, Gender, and Body Mass Index with Fasting Blood Sugar Levels in Type 2 Diabetes Mellitus Patients at the Proklamasi Outpatient Clinic, Depok, West Java. Kusuma Husada Health Journal 2020:41–50. https://doi.org/10.34035/jk.v11i1.412.
- Bellary S, Kyrou I, Brown JE, Bailey CJ. Type 2 Diabetes Mellitus in Older Adults: Clinical Considerations and Management. Nature Reviews Endocrinology 2021;17:534–48. https://doi.org/10.1038/s41574-021-00512-2.
- Libby P, Bonow R, Mann D, Tomaselli G, Bhatt D, Solomon S. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022.
- Aprilio R, Sabri R, Mahathir M. Characteristics of Patients with Type 2 Diabetes Mellitus. Indonesian Journal of Global Health Research 2024;6:2463–70. https://doi.org/10.37287/ijghr.v6i4.3676.
- Berumen J, Orozco L, Gallardo-Rincón H, Rivas F, Barrera E, Benuto RE, et al. Sex Differences in The Influence of Type 2 Diabetes (T2D)-Related Genes, Parental History of T2D, and Obesity on T2D Development: A Case–Control Study. Biology of Sex Differences 2023;14:39. https://doi.org/10.1186/s13293-023-00521-y.
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- Jameson JL. Harrison’s Endocrinology. 4th ed. New York: The McGraw-Hill Education; 2017.
- Haque T, Rahman S, Islam S, Molla NH, Ali N. Assessment of the Relationship Between Serum Uric Acid and Glucose Levels in Healthy, Prediabetic and Diabetic Individuals. Diabetology & Metabolic Syndrome 2019;11:49. https://doi.org/10.1186/s13098-019-0446-6.
- Halperin Kuhns VL, Woodward OM. Sex Differences in Urate Handling. International Journal of Molecular Sciences 2020;21:4269. https://doi.org/10.3390/ijms21124269.
- Tsai M-K, Hung K-C, Liao C-C, Pan L-F, Hung C-L, Yang D-H. The Association between Serum Testosterone and Hyperuricemia in Males. Journal of Clinical Medicine 2022;11:2743. https://doi.org/10.3390/jcm11102743.
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- Nian Y-L, You C-G. Susceptibility Genes of Hyperuricemia and Gout. Hereditas 2022;159:30. https://doi.org/10.1186/s41065-022-00243-y.
- Rangareddy H, Venkateshappa C. Serum Uric Acid Levels in Type 2 Diabetes Mellitus among South Indian Urban Population: A Cross Sectional Study. Journal of Biomedical and Pharmaceutical Research 2020;9:20–4. https://doi.org/10.32553/jbpr.v9i6.816.
- Pandey R, Humagain S, Risal P, Yadav RK, Pokhrel BR. Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients. Nepal Medical College Journal 2022;24:271–5. https://doi.org/10.3126/nmcj.v24i4.50576.
- Kussoy V, Kundre R, Wowling F. High Purine Food Eating Habits with Uric Acid Levels in Health Centers. Nursing Journal 2019;7:1–7.
References
Kementerian Kesehatan RI. Non-Communicable Disease Management Guidelines. Jakarta: Prevention and Control of Non-Communicable Diseases; 2019.
Taswin T, Nuhu RMA, Amirudin EE, Subhan M. The Relationship between Self Care and Quality of Life of Diabetes Mellitus Patients in the Bungi Health Center Work Area in Baubau City. Indonesian Health Journal 2022;12:109–15.
World Health Organization. Diabetes 2023. https://www.who.int/news-room/fact-sheets/detail/diabetes (accessed September 3, 2024).
Maulana A, Faisal FR, Noviandy TR, Rizkia T, Idroes GM, Tallei TE, et al. Machine Learning Approach for Diabetes Detection Using Fine-Tuned XGBoost Algorithm. Infolitika Journal of Data Science 2023;1:1–7. https://doi.org/10.60084/ijds.v1i1.72.
International Diabetes Federation. Facts & figures. IDF Diabetes Atlas 2021. https://idf.org/about-diabetes/diabetes-facts-figures (accessed September 3, 2024).
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice 2019;157:107843. https://doi.org/10.1016/j.diabres.2019.107843.
Ministry of Health of the Republic of Indonesia. Indonesian Health Survey. Jakarta: 2023.
Ministry of Health of the Republic of Indonesia. North Sulawesi Riskesdas Report 2018. Jakarta: 2018.
Number of Cases of 10 Most Common Diseases in Manado City - Statistical Table n.d. https://manadokota.bps.go.id/id/statistics-table/2/MTM5IzI=/jumlah-kasus-10-jenis-penyakit-terbanyak-di-kota-manado.html (accessed February 9, 2025).
Junika Rorintulus S, Amisi MD, Sanggelorang Y. Overview of the Eating Patterns of the Population Aged 18-30 Years in Bahu Village, Malalayang District, Manado City. Journal KESMAS 2022;11.
Djendra IM, Pasambuna M, Pintan S. Diet and Physical Activity Patterns in Type 2 Diabetes Mellitus Patients at Pancaran Kasih Hospital, Manado. GIZIDO 2019;11.
Tao X, Jiang M, Liu Y, Hu Q, Zhu B, Hu J, et al. Predicting Three-mMonth Fasting Blood Glucose and Glycated Hemoglobin Changes in Patients with Type 2 Diabetes Mellitus Based on Multiple Machine Learning Algorithms. Scientific Reports 2023;13:16437. https://doi.org/10.1038/s41598-023-43240-5.
Pertiwi NML, Wande I nyoman, Mulyantari NK. Prevalence of Hyperuricemia in Type 2 Diabetes Mellitus Patients at Sanglah General Hospital, Denpasar, Bali, July-December 2017. Udayana Medical Journal 2019;8:2597–8012.
Abdel KA, Kalluvya SE, Sadiq AM, Ashir A, Masikini PI. Prevalence of Hyperuricemia and Associated Factors Among Patients With Type 2 Diabetes Mellitus in Northwestern Tanzania: A Cross-Sectional Study. Clinical Medicine Insights: Endocrinology and Diabetes 2024;17. https://doi.org/10.1177/11795514241274694.
Ferrier D. Lippincott Illustrated Reviews: Biochemistry. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2021.
Lytvyn Y, Perkins BA, Cherney DZI. Uric Acid as a Biomarker and a Therapeutic Target in Diabetes. Canadian Journal of Diabetes 2015;39:239–46. https://doi.org/10.1016/j.jcjd.2014.10.013.
Kuo K-T, Chang Y-F, Wu I-H, Lu F-H, Yang Y-C, Wu J-S, et al. Differences in the Association Between Glycemia and Uric Acid Levels in Diabetic and Non-Diabetic Populations. Journal of Diabetes and Its Complications 2019;33:511–5. https://doi.org/10.1016/j.jdiacomp.2019.05.004.
Eguchi N, Vaziri ND, Dafoe DC, Ichii H. The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes. International Journal of Molecular Sciences 2021;22:1509. https://doi.org/10.3390/ijms22041509.
Newsholme P, Keane KN, Carlessi R, Cruzat V. Oxidative Stress Pathways in Pancreatic β-cells and Insulin-Sensitive Cells and Tissues: Importance to Cell Metabolism, Function, and Dysfunction. American Journal of Physiology - Cell Physiology 2019;317:C420–33. https://doi.org/10.1152/ajpcell.00141.2019/asset/images/large/zh00081984920002.jpeg.
Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis G-A, Vogiatzi G, Papaioannou S, et al. The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives. European Cardiology Review 2019;14:50–9. https://doi.org/10.15420/ecr.2018.33.1.
Xiong Q, Liu J, Xu Y. Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications. International Journal of Endocrinology 2019;2019:1–8. https://doi.org/10.1155/2019/9691345.
Rodwell VW, Bender DA, Botham KM, Kennelly PJ, Weil PAnthony. Harper’s Illustrated Biochemistry. 30th ed. Mcgraw-Hill Education; 2015.
Asma Sakalli A, Küçükerdem HS, Aygün O. What is the Relationship Between Serum Uric Acid Level and Insulin Resistance?: A Case-Control Study. Medicine 2023;102:e36732. https://doi.org/10.1097/MD.0000000000036732.
Li X, Huang B, Liu Y, Wang M, Cui J-Q. Uric Acid in Diabetic Microvascular Complications: Mechanisms and Therapy. Journal of Diabetes and Its Complications 2025;39:108929. https://doi.org/10.1016/j.jdiacomp.2024.108929.
Praditya A, Maslim Y. Relationship between Fasting Blood Sugar Levels and Serum Uric Acid Levels in Type 2 Diabetes Mellitus Patients. Damianus Journal of Medicine 2023;22:52–60. https://doi.org/10.25170/djm.v22i1.1843.
Husen F, Ratnaningtyas NI. Relationship between Uric Acid Levels and Blood Glucose in Old Adult Women in Mandiraja Wetan Village. Journal of Research and Community Service UNSIQ 2023;10:177–85. https://doi.org/10.32699/ppkm.v10i3.5371.
Komariah K, Rahayu S. Relationship of Age, Gender, and Body Mass Index with Fasting Blood Sugar Levels in Type 2 Diabetes Mellitus Patients at the Proklamasi Outpatient Clinic, Depok, West Java. Kusuma Husada Health Journal 2020:41–50. https://doi.org/10.34035/jk.v11i1.412.
Bellary S, Kyrou I, Brown JE, Bailey CJ. Type 2 Diabetes Mellitus in Older Adults: Clinical Considerations and Management. Nature Reviews Endocrinology 2021;17:534–48. https://doi.org/10.1038/s41574-021-00512-2.
Libby P, Bonow R, Mann D, Tomaselli G, Bhatt D, Solomon S. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022.
Aprilio R, Sabri R, Mahathir M. Characteristics of Patients with Type 2 Diabetes Mellitus. Indonesian Journal of Global Health Research 2024;6:2463–70. https://doi.org/10.37287/ijghr.v6i4.3676.
Berumen J, Orozco L, Gallardo-Rincón H, Rivas F, Barrera E, Benuto RE, et al. Sex Differences in The Influence of Type 2 Diabetes (T2D)-Related Genes, Parental History of T2D, and Obesity on T2D Development: A Case–Control Study. Biology of Sex Differences 2023;14:39. https://doi.org/10.1186/s13293-023-00521-y.
Kusdiantini A, Istiqomah AA. Overview of HbA1C Levels and Fasting Blood Glucose in Diabetes Mellitus Patients at Bandung Regional Public Hospital. PREPOTIF : Journal of Public Health 2024;8:4652–5. https://doi.org/10.31004/prepotif.v8i3.33317.
Warouw FM, Kandou G, Kaunang. Wulan. The Relationship between Family History and Eating Habits with Diabetes Mellitus in Patients at Tuminting Health Center, Manado City. PREPOTIF : Journal of Public Health 2024;8.
Jameson JL. Harrison’s Endocrinology. 4th ed. New York: The McGraw-Hill Education; 2017.
Haque T, Rahman S, Islam S, Molla NH, Ali N. Assessment of the Relationship Between Serum Uric Acid and Glucose Levels in Healthy, Prediabetic and Diabetic Individuals. Diabetology & Metabolic Syndrome 2019;11:49. https://doi.org/10.1186/s13098-019-0446-6.
Halperin Kuhns VL, Woodward OM. Sex Differences in Urate Handling. International Journal of Molecular Sciences 2020;21:4269. https://doi.org/10.3390/ijms21124269.
Tsai M-K, Hung K-C, Liao C-C, Pan L-F, Hung C-L, Yang D-H. The Association between Serum Testosterone and Hyperuricemia in Males. Journal of Clinical Medicine 2022;11:2743. https://doi.org/10.3390/jcm11102743.
Han Y, Zhang Y, Cao Y, Yin Y, Han X, Di H, et al. Exploration of The Association between Serum Uric Acid and Testosterone in Adult Males: NHANES 2011–2016. Translational Andrology and Urology 2021;10:272–82. https://doi.org/10.21037/tau-20-1114.
Nian Y-L, You C-G. Susceptibility Genes of Hyperuricemia and Gout. Hereditas 2022;159:30. https://doi.org/10.1186/s41065-022-00243-y.
Rangareddy H, Venkateshappa C. Serum Uric Acid Levels in Type 2 Diabetes Mellitus among South Indian Urban Population: A Cross Sectional Study. Journal of Biomedical and Pharmaceutical Research 2020;9:20–4. https://doi.org/10.32553/jbpr.v9i6.816.
Pandey R, Humagain S, Risal P, Yadav RK, Pokhrel BR. Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients. Nepal Medical College Journal 2022;24:271–5. https://doi.org/10.3126/nmcj.v24i4.50576.
Kussoy V, Kundre R, Wowling F. High Purine Food Eating Habits with Uric Acid Levels in Health Centers. Nursing Journal 2019;7:1–7.